Clinical Data Directory

Top-Level Contents

clinical/

  • readme.txt – Overview of datasets and study design.

Processed Folder

Contains cleaned datasets ready for analysis:

  • medication.csv – Medication data with blank records removed.
  • madrs.csv – Montgomery-Åsberg Depression Rating Scale scores.
  • phq9.csv – Patient Health Questionnaire-9 scores.
  • core_variables.csv – Key demographic and clinical variables.

Raw Folder

Contains original, unprocessed files and supporting documentation:

  • prs_enhanced_dropna.csv – Polygenic risk scores (missing values removed).
  • Adherence_AE_SideEffect_dictionary.pdf – Codebook for adherence and side effects.
  • AE-SideEffect_1.24.25.csv – Raw adverse events and side effects data.
  • ATHF_step1_2025-02-12.xlsx – Antidepressant treatment history form (step 1).
  • AUDIT_DAST_2025-03-28.xlsx – Substance use screening data.
  • Baseline-SideEffect-Adherence_1.24.25.csv – Baseline medication adherence and side effects.
  • CoreVariable_4.17.25.csv – Initial core variables dataset.
  • Date_1stDoseStep1_5.22.25.csv – Date of first medication dose (step 1).
  • MADRS_PHQ-9_Fall_2.25.25.xlsx – Combined MADRS and PHQ-9 scores for Fall 2025.
  • MotorTB_DataDictionary.xlsx – Codebook for motor task battery.
  • NIHTB_Cog_step1_3.28.25.csv – Cognitive testing data (step 1).
  • NIHTB_Cog_step2_3.28.25.csv – Cognitive testing data (step 2).
  • NIHTBForm_CodeBook.pdf – NIH Toolbox cognitive and motor tests reference.
  • NIHTB_Motor_4.16.25_Yi.xlsx – Motor testing dataset.
  • OPTIMUM_HeightWeightBMI_1.24.25.csv – Anthropometric data.
  • OPTIMUMMainDatabaseFinal_DataDictionary_2025-01-24.csv – Master dataset and variable dictionary.
  • OPTIMUM_Medication_1.24.25.csv – Comprehensive medication record.
  • OPTIMUM_Survey_ALLDATA_tableLOOKUP_1.24.25.csv – Survey responses and lookup.
  • OPT N Adverse Events Arm 7-8.xlsx – Adverse events data (Arms 7–8).
  • OPT N Age Arms 7-8 20250404.xlsx – Participant ages (Arms 7–8).
  • OPT N Biomarkers Arm 6.xlsx – Biomarker data (Arm 6).
  • OPT N Decision Support Form Arm 7-8.xlsx – Clinical decision support inputs.
  • OPT N Demo Arm 6.xlsx, Arm 7-8.xlsx – Demographic data.
  • OPT N Height Weight Arm 8 20250401.xlsx – Anthropometric data (Arm 8).
  • OPT N MADRS Arms6-8 Feb2025.xlsx – MADRS scores (Arms 6–8).
  • OPT N MedicalHist Arms 6-8.xlsx – Medical history forms.
  • OPT N Meds Arm 6-8.xlsx – Medication records by arm.
  • OPT N MRI Arm 6.xlsx – MRI records (Arm 6).
  • OPT N Participant Tracking Form Arm 7-8.xlsx – Participant tracking data.
  • OPT N PHQ9 Arms6-9 Feb2025.xlsx – PHQ-9 scores (Arms 6–9).
  • OPT N Psych Meds Arm 6-8.xlsx – Psychiatric medication data.
  • OPT N Randomization Groups Dates 20250401.xlsx – Randomization logs.
  • OPT N Termination Arm 6.xlsx, Arm 7-8.xlsx – Study termination data.
  • OverallDataMissingNotes_Yi_3.31.25.csv – Notes on missing data.
  • SuicideRelatedCodeBook.pdf – Codebook for suicide risk variables.
  • SuicideRiskManagemenProtocol_2025-03-28.xlsx – Suicide risk management protocol.