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The effect of mutations-caused amino acid changes on protein function was predicted by a combination of tools that use sequence homology, evolutionary conservation, and protein structural information.
The variantsfile.txt txt file was built using the information contained on Workshop_samples_05-17-23_nocont_homo_common.bim obtained at the previous step. This file should has two columns (Pos and Variant).
./mutserve annotate --input variantsfile.txt --annotation rCRS_annotation_2020-08-20.txt --output AnnotatedVariants.txt |
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https://github.com/seppinho/mutserve/blob/master/files/rCRS_annotation_descriptions.md
Interpretation of the results
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