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Krembil Centre for Neuroinformatics Summer School

Solving Problems in Mental Health using Multi-Scale Computational Neuroscience

Distribution Date: June 2022

Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health



Join us for the Krembil Centre For Neuroinformatics Open House!



Introductory Concepts (July 5, 2021)


Topic
InstructorVideoSlides

Lecture 1: Welcome and Orientation

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Lecture 2:  Problems and opportunities in the diagnosis and treatment of major depression

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Workshop 1: Guiding principles for FAIR and open science

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Workshop 2: Tools for Reproducible Science

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Computing Fundamentals

For those who need more help with computing fundamentals - going into the later content. We recommend content available from the KCNI Scientific Computing Working Group.

TopicTutorial VideosOnline TutorialsPrerequisit to
R


Python

Those working with imaging data
Git/Github


Linux/Bash




Reproducible Science (including Docker and Binder) 

2022 Watch Party Time (EST)
Session
InstructorsVideoMaterials
1:00-2:30pm
Workshop 1: Guiding principles for FAIR and open science
Erin Dickie, Sejal Patel
Watch on Crowdcast

2:45-4:15pm
Workshop 2: Tools for Reproducible Science
Erin Dickie, Sejal Patel
Watch on Crowdcast



Applied Ethics in Machine Learning and Mental Health 

2022 Watch Party Time
Topic
InstructorVideoMaterials

Lecture 1: Introduction to AI Ethics
Daniel Buchman
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Lecture 2:  Fairness and Health Equity
Marta Maslej & Laura Sikstrom
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Workshop 1: Research Design, Data Collection, Model Construction and Validation
Marta Maslej & Laura Sikstrom
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Workshop 2: Analysis, Interpretation and Knowledge Exchange and/or Translation
Marta Maslej & Laura Sikstrom
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All videos previously recorded July 6th, 2021 as part of the KCNI Summer School






Fundamental Methods for Genomic Analysis

Instructor: Dan Felsky

Time (EST)
Session

9:00-10:30
Lecture 1: Basics of genotype, central dogma, GWAS, and polygenic risk scores
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1:00-2:30pm
Workshop 1: Intro to transcriptomic data types, including single-cell and bulk RNAseq
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All videos previously recorded July 7th, 2021 as part of the KCNI Summer School

Fundamental Methods for Single-Cell Transcriptome Analysis (July 7, 2021)

Instructors:  Shreejoy Tripathy & Dan Felsky
TA's:  Keon Arbabi, Sonny Chen, Micaela Consens, Amin Kharaghani

Recorded on July 7, 2021 as a part of the Centre for Addiction and Mental Health’s Krembil Centre for Neuroinformatics (KCNI) Summer School, (CAMH KCNI SS)


Time (EST)
Session

10:45-12:15
Lecture 1:  Transcriptomics at the single-cell and bulk level level
Watch on Crowdcast
1:00-2:30pm
Workshop 1: Intro to transcriptomic data types, including single-cell and bulk RNAseq
Watch on Crowdcast
2:45-4:15pm
Workshop 2: Explore cellular changes in major depression using bulk and single-cell RNAseq data
Watch on Crowdcast

All videos previously recorded July 7th, 2021 as part of the KCNI Summer School

Simulating Brain Microcircuit Activity and Signals in Mental Health 

Instructors: Etay Hay & Frank Mazza


Watch Party Time (EST)
Session

9:00-10:30
Lecture 1: Simulating brain microcircuit activity in mental health
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10:45-12:15
Lecture 2: Simulating EEG from brain microcircuits in mental health
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1:00-2:30pm
Workshop 1: Simulating and analyzing spiking from neurons and microcircuits
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2:45-4:15pm
Workshop 2: Simulating and analyzing EEG signals from brain microcircuits
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All videos previously recorded July 8th, 2021 as part of the KCNI Summer School

Day 5: Whole-Brain Modelling and Neuroimaging Connectomics (July 9, 2021)

Instructors: Erin Dickie & John Griffiths
TA's: Shreyas Harita, Jerrold Jeyachandra, Kevin Kadak
Time (EST)
Session

9:00-10:30
Lecture 1: Introduction to neuroimaging connectomics
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10:45-12:15
Workshop 1: Calculating Neuroimaging Connectomes
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1:00-2:30pm
Lecture 2: Intro to whole-brain modelling (Lecture)
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2:45-4:15pm
Workshop 2: simulating whole-brain activity, EEG, evoked responses, brain stimulation
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Day 6: Bayesian Models of Learning and Integration of Neuroimaging Data (July 12, 2021)

Instructors: Andreea Diaconescu
TA's: Colleen Charlton, Daniel Hauke, Peter Bedford, Povilas Karvelis
Time (EST)
Session

9:00-10:30
Lecture 1: Bayesian Models of Learning
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10:45-12:15
Turorial 1:  Hierarchical Gaussian Filter and Simulating Learners
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1:00-2:30pm
Lecture 2: Computational Modelling of EEG Data
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2:45-4:15pm
Tutorial 2: Single-trial EEG Modelling
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Digital Health and Population-Based Data Resources (July 13, 2021)

Instructors: Daniel Felsky, Abhi Pratap & Joanna Yu
TA's: Mohamed Abdelhack, Grace Jacobs, Amin Kharaghani, Marta Maslej, Milos Milic, Earvin Tio


Time (EST)
Session

9:00-10:30
Lecture 1: Digital Health for Mental health

Presented by Abhi Pratap 

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10:45-12:15
Lecture 2: Population-based resources and the BrainHealth Databank
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1:00-2:30pm
Workshop 1: accessing reproducible datasets from Synapse as part of integrated workflow
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2:45-4:15pm
Workshop 2: Introduction to interactive methods
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Integrative Research Methods and Final Panel Discussion (July 14, 2021)

Instructors: Daniel Felsky & Abhi Pratap + All Instructor Panel
TA's: Mohamed Abdelhack, Amin Kharaghani, Marta Maslej, Milos Milic, Earvin Tio
Time (EST)
Session


Lecture 2: Population-based resources and the BrainHealth Databank


Workshop 2: Introduction to interactive methods

9:00-10:30
Lecture 1: Types of integrative research and Whole Person Modelling
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10:45-12:15
Workshop: SNF / Subtyping
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1:00-2:30pm

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2:45-4:15pm



Additional Lecture Content (no zoom Q&A event)

"A Multiscale Approach to Brain Disorders” - presented by Sean Hill, 

Presented by: Sean Hill, Ph.D. Director, Krembil Centre for Neuroinformatics Senior Scientist, Centre for Addiction and Mental Health Professor, Departments of Psychiatry and Physiology, University of Toronto, Canada Titular Professor, École Polytechnique Fédérale de Lausanne, Switzerland krembilneuroinformatics.ca

Recorded on July 5, 2021 as a part of the Centre for Addiction and Mental Health’s Krembil Centre for Neuroinformatics (KCNI) Summer School, (CAMH KCNI SS)

Slides available from:  https://github.com/krembilneuroinformatics/kcni-school-lessons/blob/8ef714f18125ff7f905ef61c97a995bc18e705a2/day1/KCNISS_day1_1_Hill-compressed.pdf

KCNI Summer School schedule and materials at:  https://github.com/krembilneuroinformatics/kcni-school-lessons

© Centre for Addiction and Mental Health, all rights reserved.


Lecture:  “A Multiscale Approach to Brain Disorders”

Presented by: Sean Hill, Ph.D. Director, Krembil Centre for Neuroinformatics Senior Scientist, Centre for Addiction and Mental Health Professor, Departments of Psychiatry and Physiology, University of Toronto, Canada Titular Professor, École Polytechnique Fédérale de Lausanne, Switzerland krembilneuroinformatics.ca

Recorded on July 5, 2021 as a part of the Centre for Addiction and Mental Health’s Krembil Centre for Neuroinformatics (KCNI) Summer School, (CAMH KCNI SS)

Slides available from:  https://github.com/krembilneuroinformatics/kcni-school-lessons/blob/8ef714f18125ff7f905ef61c97a995bc18e705a2/day1/KCNISS_day1_1_Hill-compressed.pdf

KCNI Summer School schedule and materials at:  https://github.com/krembilneuroinformatics/kcni-school-lessons

© Centre for Addiction and Mental Health, all rights reserved.

Problems and opportunities in the diagnosis and treatment of major depression. Speakers: Victor Tang, Brett Jones, Recorded July 5, 2021

2020 Summer School Overview


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